Technology in Parkinson's disease: Challenges and opportunities.
Identifieur interne : 000186 ( Main/Exploration ); précédent : 000185; suivant : 000187Technology in Parkinson's disease: Challenges and opportunities.
Auteurs : Alberto J. Espay [États-Unis] ; Paolo Bonato [États-Unis] ; Fatta B. Nahab [États-Unis] ; Walter Maetzler [Allemagne] ; John M. Dean [États-Unis] ; Jochen Klucken [Allemagne] ; Bjoern M. Eskofier [Allemagne] ; Aristide Merola [Italie] ; Fay Horak [États-Unis] ; Anthony E. Lang [Canada] ; Ralf Reilmann [Allemagne] ; Joe Giuffrida [États-Unis] ; Alice Nieuwboer [Belgique] ; Malcolm Horne [Australie] ; Max A. Little [Royaume-Uni] ; Irene Litvan [États-Unis] ; Tanya Simuni [États-Unis] ; E Ray Dorsey [États-Unis] ; Michelle A. Burack [États-Unis] ; Ken Kubota [États-Unis] ; Anita Kamondi [Hongrie] ; Catarina Godinho [Portugal] ; Jean-Francois Daneault [États-Unis] ; Georgia Mitsi [États-Unis] ; Lothar Krinke [États-Unis] ; Jeffery M. Hausdorff [Israël] ; Bastiaan R. Bloem [Pays-Bas] ; Spyros Papapetropoulos [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.
DOI: 10.1002/mds.26642
PubMed: 27125836
Affiliations:
- Allemagne, Australie, Belgique, Canada, Hongrie, Israël, Italie, Pays-Bas, Portugal, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, Californie, Colorado, District de Moyenne-Franconie, District de Tübingen, Gueldre, Hongrie centrale, Illinois, Massachusetts, Midlands de l'Ouest, Minnesota, Ohio, Oregon, Piémont, État de New York
- Birmingham, Budapest, Erlangen, Nimègue, Turin, Tübingen
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Hausdorff</name><affiliation wicri:level="1"><nlm:affiliation>Sackler School of Medicine, Tel Aviv University and Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Sackler School of Medicine, Tel Aviv University and Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. Bloem</name><affiliation wicri:level="3"><nlm:affiliation>Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Papapetropoulos, Spyros" sort="Papapetropoulos, Spyros" uniqKey="Papapetropoulos S" first="Spyros" last="Papapetropoulos">Spyros Papapetropoulos</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27125836</idno><idno type="pmid">27125836</idno><idno type="doi">10.1002/mds.26642</idno><idno type="wicri:Area/PubMed/Corpus">000170</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000170</idno><idno type="wicri:Area/PubMed/Curation">000170</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000170</idno><idno type="wicri:Area/PubMed/Checkpoint">000170</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000170</idno><idno type="wicri:Area/Ncbi/Merge">001F58</idno><idno type="wicri:Area/Ncbi/Curation">001F58</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F58</idno><idno type="wicri:Area/Main/Merge">000186</idno><idno type="wicri:Area/Main/Curation">000186</idno><idno type="wicri:Area/Main/Exploration">000186</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Technology in Parkinson's disease: Challenges and opportunities.</title><author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. 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Gardner Family Center for Parkinson's disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Bonato, Paolo" sort="Bonato, Paolo" uniqKey="Bonato P" first="Paolo" last="Bonato">Paolo Bonato</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Nahab, Fatta B" sort="Nahab, Fatta B" uniqKey="Nahab F" first="Fatta B" last="Nahab">Fatta B. Nahab</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tuebingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tuebingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Dean, John M" sort="Dean, John M" uniqKey="Dean J" first="John M" last="Dean">John M. Dean</name><affiliation wicri:level="2"><nlm:affiliation>Davis Phinney Foundation for Parkinson's, Boulder, Colorado, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Davis Phinney Foundation for Parkinson's, Boulder, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Klucken, Jochen" sort="Klucken, Jochen" uniqKey="Klucken J" first="Jochen" last="Klucken">Jochen Klucken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Eskofier, Bjoern M" sort="Eskofier, Bjoern M" uniqKey="Eskofier B" first="Bjoern M" last="Eskofier">Bjoern M. Eskofier</name><affiliation wicri:level="3"><nlm:affiliation>Digital Sports Group, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Digital Sports Group, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Merola, Aristide" sort="Merola, Aristide" uniqKey="Merola A" first="Aristide" last="Merola">Aristide Merola</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuroscience "Rita Levi Montalcini", Città della salute e della scienza di Torino, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience "Rita Levi Montalcini", Città della salute e della scienza di Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Horak, Fay" sort="Horak, Fay" uniqKey="Horak F" first="Fay" last="Horak">Fay Horak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Oregon Health & Science University, Portland VA Medical System, Portland, Oregon.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Neurology, Oregon Health & Science University, Portland VA Medical System, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name><affiliation wicri:level="1"><nlm:affiliation>George-Huntington-Institute, Muenster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>George-Huntington-Institute, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Giuffrida, Joe" sort="Giuffrida, Joe" uniqKey="Giuffrida J" first="Joe" last="Giuffrida">Joe Giuffrida</name><affiliation wicri:level="2"><nlm:affiliation>Great Lakes NeuroTechnologies, Cleveland, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Great Lakes NeuroTechnologies, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name><affiliation wicri:level="1"><nlm:affiliation>Neuromotor Rehabilitation Research Group, Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Neuromotor Rehabilitation Research Group, Department of Rehabilitation Sciences, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Horne, Malcolm" sort="Horne, Malcolm" uniqKey="Horne M" first="Malcolm" last="Horne">Malcolm Horne</name><affiliation wicri:level="1"><nlm:affiliation>Global Kinetics Corporation & Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Global Kinetics Corporation & Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Little, Max A" sort="Little, Max A" uniqKey="Little M" first="Max A" last="Little">Max A. Little</name><affiliation wicri:level="3"><nlm:affiliation>Department of Mathematics, Aston University, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Mathematics, Aston University, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Dorsey, E Ray" sort="Dorsey, E Ray" uniqKey="Dorsey E" first="E Ray" last="Dorsey">E Ray Dorsey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Burack, Michelle A" sort="Burack, Michelle A" uniqKey="Burack M" first="Michelle A" last="Burack">Michelle A. Burack</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kubota, Ken" sort="Kubota, Ken" uniqKey="Kubota K" first="Ken" last="Kubota">Ken Kubota</name><affiliation wicri:level="2"><nlm:affiliation>Michael J Fox Foundation for Parkinson's Research, New York City, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Michael J Fox Foundation for Parkinson's Research, New York City, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kamondi, Anita" sort="Kamondi, Anita" uniqKey="Kamondi A" first="Anita" last="Kamondi">Anita Kamondi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, National Institute of Clinical Neurosciences, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurology, National Institute of Clinical Neurosciences, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Godinho, Catarina" sort="Godinho, Catarina" uniqKey="Godinho C" first="Catarina" last="Godinho">Catarina Godinho</name><affiliation wicri:level="1"><nlm:affiliation>Center of Interdisciplinary Research Egas Moniz (CiiEM), Instituto Superior de Ciências da Saúde Egas Moniz, Monte de Caparica, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Center of Interdisciplinary Research Egas Moniz (CiiEM), Instituto Superior de Ciências da Saúde Egas Moniz, Monte de Caparica</wicri:regionArea><wicri:noRegion>Monte de Caparica</wicri:noRegion></affiliation></author><author><name sortKey="Daneault, Jean Francois" sort="Daneault, Jean Francois" uniqKey="Daneault J" first="Jean-Francois" last="Daneault">Jean-Francois Daneault</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mitsi, Georgia" sort="Mitsi, Georgia" uniqKey="Mitsi G" first="Georgia" last="Mitsi">Georgia Mitsi</name><affiliation wicri:level="2"><nlm:affiliation>Apptomics LLC, Wellesley, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Apptomics LLC, Wellesley, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Krinke, Lothar" sort="Krinke, Lothar" uniqKey="Krinke L" first="Lothar" last="Krinke">Lothar Krinke</name><affiliation wicri:level="2"><nlm:affiliation>Medtronic Neuromodulation, Minneapolis, Minnesota, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medtronic Neuromodulation, Minneapolis, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Hausdorff, Jeffery M" sort="Hausdorff, Jeffery M" uniqKey="Hausdorff J" first="Jeffery M" last="Hausdorff">Jeffery M. Hausdorff</name><affiliation wicri:level="1"><nlm:affiliation>Sackler School of Medicine, Tel Aviv University and Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Sackler School of Medicine, Tel Aviv University and Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. Bloem</name><affiliation wicri:level="3"><nlm:affiliation>Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Papapetropoulos, Spyros" sort="Papapetropoulos, Spyros" uniqKey="Papapetropoulos S" first="Spyros" last="Papapetropoulos">Spyros Papapetropoulos</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Hongrie</li><li>Israël</li><li>Italie</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>Californie</li><li>Colorado</li><li>District de Moyenne-Franconie</li><li>District de Tübingen</li><li>Gueldre</li><li>Hongrie centrale</li><li>Illinois</li><li>Massachusetts</li><li>Midlands de l'Ouest</li><li>Minnesota</li><li>Ohio</li><li>Oregon</li><li>Piémont</li><li>État de New York</li></region><settlement><li>Birmingham</li><li>Budapest</li><li>Erlangen</li><li>Nimègue</li><li>Turin</li><li>Tübingen</li></settlement></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name></region><name sortKey="Bonato, Paolo" sort="Bonato, Paolo" uniqKey="Bonato P" first="Paolo" last="Bonato">Paolo Bonato</name><name sortKey="Burack, Michelle A" sort="Burack, Michelle A" uniqKey="Burack M" first="Michelle A" last="Burack">Michelle A. Burack</name><name sortKey="Daneault, Jean Francois" sort="Daneault, Jean Francois" uniqKey="Daneault J" first="Jean-Francois" last="Daneault">Jean-Francois Daneault</name><name sortKey="Dean, John M" sort="Dean, John M" uniqKey="Dean J" first="John M" last="Dean">John M. Dean</name><name sortKey="Dorsey, E Ray" sort="Dorsey, E Ray" uniqKey="Dorsey E" first="E Ray" last="Dorsey">E Ray Dorsey</name><name sortKey="Giuffrida, Joe" sort="Giuffrida, Joe" uniqKey="Giuffrida J" first="Joe" last="Giuffrida">Joe Giuffrida</name><name sortKey="Horak, Fay" sort="Horak, Fay" uniqKey="Horak F" first="Fay" last="Horak">Fay Horak</name><name sortKey="Krinke, Lothar" sort="Krinke, Lothar" uniqKey="Krinke L" first="Lothar" last="Krinke">Lothar Krinke</name><name sortKey="Kubota, Ken" sort="Kubota, Ken" uniqKey="Kubota K" first="Ken" last="Kubota">Ken Kubota</name><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><name sortKey="Mitsi, Georgia" sort="Mitsi, Georgia" uniqKey="Mitsi G" first="Georgia" last="Mitsi">Georgia Mitsi</name><name sortKey="Nahab, Fatta B" sort="Nahab, Fatta B" uniqKey="Nahab F" first="Fatta B" last="Nahab">Fatta B. Nahab</name><name sortKey="Papapetropoulos, Spyros" sort="Papapetropoulos, Spyros" uniqKey="Papapetropoulos S" first="Spyros" last="Papapetropoulos">Spyros Papapetropoulos</name><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name></region><name sortKey="Eskofier, Bjoern M" sort="Eskofier, Bjoern M" uniqKey="Eskofier B" first="Bjoern M" last="Eskofier">Bjoern M. Eskofier</name><name sortKey="Klucken, Jochen" sort="Klucken, Jochen" uniqKey="Klucken J" first="Jochen" last="Klucken">Jochen Klucken</name><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name></country><country name="Italie"><region name="Piémont"><name sortKey="Merola, Aristide" sort="Merola, Aristide" uniqKey="Merola A" first="Aristide" last="Merola">Aristide Merola</name></region></country><country name="Canada"><noRegion><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Horne, Malcolm" sort="Horne, Malcolm" uniqKey="Horne M" first="Malcolm" last="Horne">Malcolm Horne</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Little, Max A" sort="Little, Max A" uniqKey="Little M" first="Max A" last="Little">Max A. Little</name></region></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Kamondi, Anita" sort="Kamondi, Anita" uniqKey="Kamondi A" first="Anita" last="Kamondi">Anita Kamondi</name></region></country><country name="Portugal"><noRegion><name sortKey="Godinho, Catarina" sort="Godinho, Catarina" uniqKey="Godinho C" first="Catarina" last="Godinho">Catarina Godinho</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Hausdorff, Jeffery M" sort="Hausdorff, Jeffery M" uniqKey="Hausdorff J" first="Jeffery M" last="Hausdorff">Jeffery M. Hausdorff</name></noRegion></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. Bloem</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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